Guidelines to the use of laboratory animals: what about neuromuscular blocking agents?

Guidelines to the use of laboratory animals: what about neuromuscular blocking agents?

Cardiovascular Research requires that investigations in blocking agents could completely eliminate the problem of animals conform with the Guide for the Care and Use of awareness. Laboratory Animals published by the US National InstiWhy are neuromuscular blocking agents still in use if tutes of Health. These guidelines advocate that neurothey are to blame for the occurrence of awareness? muscul...

tracheal intubation without the use of neuromuscular blocking agents

Never use neuromuscular blocking agents for sedation.

We read with appreciation and concern the review article by Isenstein et al,’ which appeared in the October 1992 issue of Chest. The authors have provided clinically relevant information that is familiar to most anesthesiologists, but it may not be the case for other specialists. With more newly available drugs and better monitoring techniques, there is a current trend toward increasing usage o...

Are neuromuscular blocking agents being misused in laboratory pigs?

The literature (2012-4) describing experimental pig surgery was reviewed to estimate the extent to which neuromuscular block (NMB) is used, to examine methods for ensuring unconsciousness, and to identify the rationale for use of NMB and establish the anaesthetist's training. In the first stage of a two-stage review, NMB use was estimated using Web of Knowledge to identify articles describing N...

Tracheal Intubation Without the Use of Neuromuscular Blocking Agents

I read with keen interest the article by Imani et al. (1) in which the authors compare tracheal intubating conditions following intravenous (IV) administration of remifentanil 5 μg/kg or alfentanil 50 μg/kg followed by induction of anesthesia with propofol 2 mg/kg in 100 adult patients premedicated with IV midazolam 1 mg. Intubating conditions were assessed (scoring 1 to 4) by ease of laryngosc...